ALNYLAM PHARMACEUTICALS INC

NASDAQ: ALNY (Alnylam Pharmaceuticals, Inc.)

Last update: 9 hours ago

255.76

-14.26 (-5.28%)

Previous Close 270.02
Open 272.52
Volume 867,682
Avg. Volume (3M) 797,698
Market Cap 33,102,247,936
Price / Earnings (Forward) 909.09
Price / Sales 14.52
Price / Book 493.41
52 Weeks Range
141.98 (-44%) — 304.39 (19%)
Earnings Date 30 Apr 2025 - 5 May 2025
Profit Margin -12.37%
Operating Margin (TTM) -17.73%
Diluted EPS (TTM) -2.17
Quarterly Revenue Growth (YOY) 34.90%
Total Debt/Equity (MRQ) 4,089.28%
Current Ratio (MRQ) 2.78
Operating Cash Flow (TTM) -8.31 M
Levered Free Cash Flow (TTM) 197.88 M
Return on Assets (TTM) -2.74%

Market Trend

Short Term Medium Term
Industry Biotechnology (US) Mixed Mixed
Biotechnology (Global) Mixed Mixed
Stock Alnylam Pharmaceuticals, Inc. Bullish Bullish

AIStockmoo Score

1.5
Analyst Consensus 4.0
Insider Activity -2.5
Price Volatility 2.0
Technical Moving Averages 0.0
Technical Oscillators 4.0
Average 1.50

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Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.

Sector Healthcare
Industry Biotechnology
Investment Style Mid Core
% Held by Insiders 3.87%
% Held by Institutions 96.39%

Ownership

Name Date Shares Held
Regeneron Pharmaceuticals, Inc. 31 Dec 2024 4,444,445
Wellington Management Group Llp 31 Dec 2024 4,196,623
Baillie Gifford & Co 31 Dec 2024 4,040,259
52 Weeks Range
141.98 (-44%) — 304.39 (19%)
Price Target Range
284.00 (11%) — 500.00 (95%)
High 500.00 (HC Wainwright & Co., 95.50%) Buy
Median 329.00 (28.64%)
Low 284.00 (Morgan Stanley, 11.04%) Hold
Average 340.36 (33.08%)
Total 12 Buy, 2 Hold
Avg. Price @ Call 272.98
Firm Date Target Price Call Price @ Call
Redburn Atlantic 31 Mar 2025 353.00 (38.02%) Buy 270.02
Scotiabank 31 Mar 2025 342.00 (33.72%) Buy 270.02
21 Mar 2025 338.00 (32.16%) Buy 283.34
Stifel 31 Mar 2025 345.00 (34.89%) Buy 270.02
JP Morgan 24 Mar 2025 328.00 (28.25%) Buy 290.70
11 Mar 2025 280.00 (9.48%) Hold 238.74
B of A Securities 21 Mar 2025 325.00 (27.07%) Buy 283.34
Canaccord Genuity 21 Mar 2025 390.00 (52.49%) Buy 283.34
18 Feb 2025 385.00 (50.53%) Buy 250.00
Chardan Capital 21 Mar 2025 300.00 (17.30%) Buy 283.34
26 Feb 2025 300.00 (17.30%) Buy 243.86
Citigroup 21 Mar 2025 351.00 (37.24%) Buy 283.34
Needham 21 Mar 2025 320.00 (25.12%) Buy 283.34
26 Feb 2025 320.00 (25.12%) Buy 243.86
RBC Capital 21 Mar 2025 330.00 (29.03%) Buy 283.34
26 Feb 2025 310.00 (21.21%) Buy 243.86
Wells Fargo 21 Mar 2025 287.00 (12.21%) Hold 283.34
HC Wainwright & Co. 25 Feb 2025 500.00 (95.50%) Buy 245.20
24 Feb 2025 500.00 (95.50%) Buy 248.94
Morgan Stanley 14 Feb 2025 284.00 (11.04%) Hold 256.45
Bernstein 07 Jan 2025 310.00 (21.21%) Buy 235.95
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Name Avg. Buy ($) Avg. Sell ($) Net Quantity Net Value ($)
GARG PUSHKAL - 287.02 -9,766 -2,807,174
PYOTT DAVID E I - 290.70 -7,440 -2,162,808
Aggregate Net Quantity -17,206
Aggregate Net Value ($) -4,969,982
Aggregate Avg. Buy ($) -
Aggregate Avg. Sell ($) 288.25
Name Holder Date Type Quantity Price Value ($)
PYOTT DAVID E I Director 24 Mar 2025 Automatic sell (-) 7,440 290.70 2,162,808
PYOTT DAVID E I Director 24 Mar 2025 Option execute 7,440 - -
GARG PUSHKAL Officer 24 Mar 2025 Automatic sell (-) 5,445 290.70 1,582,862
GARG PUSHKAL Officer 24 Mar 2025 Option execute 5,445 - -
GARG PUSHKAL Officer 21 Mar 2025 Automatic sell (-) 4,321 283.34 1,224,312
Date Type Details
01 Apr 2025 Announcement Alnylam to Webcast Presentation at Needham 24th Annual Virtual Healthcare Conference
29 Mar 2025 Announcement Alnylam Presents New Data from the HELIOS-B Phase 3 Study of Vutrisiran in Patients with ATTR Amyloidosis with Cardiomyopathy (ATTR-CM) at the American College of Cardiology’s Annual Scientific Session 2025
28 Mar 2025 Announcement FDA Approves Qfitlia™ (fitusiran), the First siRNA (RNAi Therapeutic) for the Treatment of Hemophilia A or B
20 Mar 2025 Announcement Alnylam Announces FDA Approval of AMVUTTRA® (vutrisiran), the First RNAi Therapeutic to Reduce Cardiovascular Death, Hospitalizations and Urgent Heart Failure Visits in Adults with ATTR Amyloidosis with Cardiomyopathy (ATTR-CM)
11 Mar 2025 Announcement Alnylam to Webcast Presentation at Stifel 2025 Virtual CNS Forum
05 Mar 2025 Announcement Alnylam Announces Retirement of Longtime Board Member, Dr. Phillip A. Sharp, Company Co-Founder and Industry Luminary
25 Feb 2025 Announcement Alnylam Highlights Significant Pipeline Progress and Platform Innovation at R&D Day
13 Feb 2025 Announcement Alnylam Pharmaceuticals Reports Fourth Quarter and Full Year 2024 Financial Results and Highlights Recent Period Progress
30 Jan 2025 Announcement Alnylam to Webcast Conference Call Discussing Fourth Quarter and Full Year 2024 Financial Results
12 Jan 2025 Announcement Alnylam Announces Preliminary* Fourth Quarter and Full Year 2024 Global Net Product Revenues and Provides 2025 Combined Net Product Revenue Guidance and Pipeline Goals
06 Jan 2025 Announcement Alnylam to Webcast Presentation at 43rd Annual J.P. Morgan Healthcare Conference
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